The Basic Science of OnabotulinumtoxinA and Erection Physiology

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Thread 'A NOVEL ULTRASOUND TECHNIQUE CAN PREDICT EFFICACY OF BOTOX INJECTION IN PATIENTS WITH ED'

Objectives

Erectile dysfunction (ED) is the inability to get or keep an erection for sexual activity, affecting 5–20% of men worldwide. Starting from 2016, botulinum neurotoxin was tested for treating ED after a human pilot trial. Shear wave elastosonography (SWE) is one of the ultrasound techniques that can be applied to assess corporal tissue stiffness. We aimed to evaluate the SWE predictability of the outcome of a penile Botox injection.


Methods

Twenty men aged 18–70 with erectile dysfunction and PDE5I non-responders participated in the outpatient...
 
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madman

Thread 'INTRACAVERNOSAL BOTULINUM TOXIN USE IN THE TREATMENT OF ED'



Introduction

Erectile dysfunction (ED) is a significant public health issue that greatly impacts patients’ quality of life. Its prevalence increases with age and is associated with several risk factors, including diabetes, hypertension, hypercholesterolemia, smoking, sedentary lifestyle, obesity, and hypogonadism. These factors often lead to vascular endothelial alterations, resulting in atherosclerosis, arterial obstruction, and reduced penile blood flow. Traditional treatments for ED focus on...
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