Melatonin: functional significance for optimal cellular physiology - Prof. Russel Reiter (14/11/19)

Fernando Almaguer · Feb 4, 2025

I like to take a long release melatonin before bed. Sometimes with ashwagandha. Especially if I am on a night shift.

Seagal · Feb 5, 2025

That's strange. I took 5mg melatonin the past days (in a addition to the 1mg time released I normally take) and my joints feel dry. Knee pain increased.
Anybody experienced that?

Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review - PMC

Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by ...

pmc.ncbi.nlm.nih.gov

https://www.jbc.org/article/S0021-9258(20)72870-X/fulltext

Fernando Almaguer · Feb 5, 2025

Seagal said:
That's strange. I took 5mg melatonin the past days (in a addition to the 1mg time released I normally take) and my joints feel dry. Knee pain increased.
Anybody experienced that?

Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review - PMC

Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by ...

pmc.ncbi.nlm.nih.gov

https://www.jbc.org/article/S0021-9258(20)72870-X/fulltext

I have not

Vince · Feb 5, 2025

Seagal said:
That's strange. I took 5mg melatonin the past days (in a addition to the 1mg time released I normally take) and my joints feel dry. Knee pain increased.
Anybody experienced that?

Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review - PMC

Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by ...

pmc.ncbi.nlm.nih.gov

https://www.jbc.org/article/S0021-9258(20)72870-X/fulltext

Both me and my wife take 120 mg every night. My joints feel great. No issues.