TNE (test base) once daily timing to preserve HPTA function

EnhancedUki · Jan 12, 2025

39 male. Mixed training for 15+ years. Have run a few 6-8 week test/var/and SARMS cycles (rad140, mk2866). Regularly cycle GHRH/GHRP cycles for anti-ageing and skin. Have experimented with Enclo and kisspeptin to increase LH/FSH with some success. Love Proviron. Never been on TRT. Very sensitive to aromatization. Currently on Raloxifene for 4 weeks (planning to run to 16) to get rid of some stubborn left side gyno.

Thinking of experimenting TNE (test base in oil) once daily at 10, 15, 20mg and measuring the results of the HPTA’s ability of returning to baseline via blood tests. Will do as many tests as needed/can afford in the name science.

Questions:

Any other tests I should do apart from TT, FT, SHBG, E2?
So far thinking to do 2 hours post injection, then next day 2 hours before injection (same time), then 2 hours before injection time 3-4 weeks later. Repeat with each of the dosages 10, 15, 20. Suggestions?
If I continue running Raloxifene (60mg daily), Aromasin 12.5 EOD (I have to for aromatization) and Proviron at 25mg ED (below suppressive dosage) and I don’t stop or change doses (so all things being equal) throughout the experiment, will blood tests be accurate in showing the HPTAs ability to return to pre-injection baseline?
I’ve noticed that for the once/daily TNE protocol everyone mentions morning injections. But, as our endogenous test peaks (~8am), and if we aim to preserve HPTA function, would it make more sense to take advantage of this fact and administer the daily IM/SubQ injection in the afternoon instead?

Thoughts and feedback appreciated!

EnhancedUki · Jan 12, 2025

EnhancedUki said:
39 male. Mixed training for 15+ years. Have run a few 6-8 week test/var/and SARMS cycles (rad140, mk2866). Regularly cycle GHRH/GHRP cycles for anti-ageing and skin. Have experimented with Enclo and kisspeptin to increase LH/FSH with some success. Love Proviron. Never been on TRT. Very sensitive to aromatization. Currently on Raloxifene for 4 weeks (planning to run to 16) to get rid of some stubborn left side gyno.

Thinking of experimenting TNE (test base in oil) once daily at 10, 15, 20mg and measuring the results of the HPTA’s ability of returning to baseline via blood tests. Will do as many tests as needed/can afford in the name science.

Questions:

Any other tests I should do apart from TT, FT, SHBG, E2?

So far thinking to do 2 hours post injection, then next day 2 hours before injection (same time), then 2 hours before injection time 3-4 weeks later. Repeat with each of the dosages 10, 15, 20. Suggestions?

If I continue running Raloxifene (60mg daily), Aromasin 12.5 EOD (I have to for aromatization) and Proviron at 25mg ED (below suppressive dosage) and I don’t stop or change doses (so all things being equal) throughout the experiment, will blood tests be accurate in showing the HPTAs ability to return to pre-injection baseline?

I’ve noticed that for the once/daily TNE protocol everyone mentions morning injections. But, as our endogenous test peaks (~8am), and if we aim to preserve HPTA function, would it make more sense to take advantage of this fact and administer the daily IM/SubQ injection in the afternoon instead?

Thoughts and feedback appreciated!

Also whats everyone’s thoughts on using low-dose Enclo EOD and/or Kisspeptin few times a week to help the endogenous production via LH/FSH stimulation (along with TNE shots)?

DixieWrecked · Jan 13, 2025

I think it would be an experiment worth trying for sure. I say go for it and report back how it went. I think you would like it.

Cataceous · Jan 16, 2025

It would be very helpful to the TRT community to have a better understanding of the pharmacokinetics of TNE. Our best guess is that TNE is not as fast acting as nasal gels and buccal troches. This could make it comparable to some of the oral formulations. In any case, it would be great to have some hard data.

My suggestion is to skip trying multiple doses and concentrate on measuring the response curve of one dose, say 10 mg. Doing this right gets complicated in a hurry. I know you'd like to observe HPTA suppression, but I think the best bet is to do this indirectly by finding the half-life of TNE. The problem is that if your HPTA is functioning then your—variable—endogenous testosterone is added to what you've injected. And worse, the exogenous testosterone has suppressive effects that are not known in advance. This makes it difficult to separate out the various effects. The ideal way to do this is to knock out your HPTA for a few days with a long-acting GnRH analog, then run your test. Measure a pre-injection baseline for testosterone, which should be very low, then test after each hour for four hours, and then maybe run a final test 8-12 hours post-injection. One of the tests should include SHBG and albumin so you can estimate free testosterone for all readings. The total cost of this is comparable to the three trials you were proposing.

TNE (test base) once daily timing to preserve HPTA function

EnhancedUki

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EnhancedUki

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DixieWrecked

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