Zyosted hct

Hi all,

I have been on Zyosted 50 mg once a week since April 2024, never had an issue till now my recent blood test result is Hemoglobin 16.5 and Hematocrit is 50.9. Dr. wants me to do 1 unit blood draw. First time ever for me..
I have a couple of question for anyone who already has experience on this. Do I need to get this done asap or can I wait couple of weeks? Is there any suggestions on getting prepared initially? And afterwards to help my body recover faster? Can I continue with my TRT 1 a week injection while recovering? How about working out after the blood draw?

Any and all responses are appreciated,

ZALEMAX said:

Hi all,

I have been on Zyosted 50 mg once a week since April 2024, never had an issue till now my recent blood test result is Hemoglobin 16.5 and Hematocrit is 50.9. Dr. wants me to do 1 unit blood draw. First time ever for me..
I have a couple of question for anyone who already has experience on this. Do I need to get this done asap or can I wait couple of weeks? Is there any suggestions on getting prepared initially? And afterwards to help my body recover faster? Can I continue with my TRT 1 a week injection while recovering? How about working out after the blood draw?

Any and all responses are appreciated,

Click to expand...

Were your properly hydrated (fluids/electrolytes) days before your blood draw?

Even then if you have no underlying health issues and are not experiencing any negative sides most doctors in the know specializing in testosterone therapy would not fret if the patient's hematocrit falls within 50-54%.

Yes some will be more cautious and take measures once hematocrit hits 52% let alone many of the uniformed will hesitate and jump the gun once it hits the top-end of the reference range and are dead set on keeping hematocrit <50%.

Would tread light when it comes to getting caught up on that donating too frequently merry go round as it is pretty much a given that you will eventually crash your iron/ferritin which can open up another can of worms.

You are on the lowest end dose of Xyosted (TE) and it is highly doubtful you are even hitting a healthy let alone high-end trough (7 days post-injection) FT.

Most using Xyosted are injecting 75-100 mg/week and the 100 mg dose would be more common!

Where does your trough TT/FT level sit on your current protocol?

Would give it 24 hrs after donating blood before doing any strenuous activity!

madman said:

Were your properly hydrated (fluids/electrolytes) days before your blood draw?

Even then if you have no underlying health issues and are not experiencing any negative sides most doctors in the know specializing in testosterone therapy would not fret if the patient's hematocrit falls within 50-54%.

Yes some will be more cautious and take measures once hematocrit hits 52% let alone many of the uniformed will hesitate and jump the gun once it hits the top-end of the reference range and are dead set on keeping hematocrit <50%.

Would tread light when it comes to getting caught up on that donating too frequently merry go round as it is pretty much a given that you will eventually crash your iron/ferritin which can open up another can of worms.

You are on the lowest end dose of Xyosted (TE) and it is highly doubtful you are even hitting a healthy let alone high-end trough (7 days post-injection) FT.

Most using Xyosted are injecting 75-100 mg/week and the 100 mg dose would be more common!

Where does your trough TT/FT level sit on your current protocol?

Would give it 24 hrs after donating blood before doing any strenuous activity!

High Testosterone on only 80mg/week

Also please enlighten us on where you attended medical school and where you got your degree in endocrinology? Your argument is small-minded and weak. If I told you, the moon revolves around the earth and the earth revolves around the sun, so by your logic, I don’t know what I’m talking about...

www.excelmale.com

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All, I react very badly to injectable T (56 hematocrit @ 100 mg split 3x per week SubQ). My ferritin suffers greatly here and sits in the 20's to low 30's. I want it to be above 70. Testosterone have given me a severe case of periodic limb movement disorder due to low dopamine resulting (I...

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@madman not sure 100% how much water I drank before the blood test on or days before but, I had water with me.. I don't think that the effect of the the water consumption is the cause of the upper limit hct. But, from now I'll pay more attention to the amount.

I have some calcium build up in my arteries I'm in the 900'z (Calc score) I take a low dose aspirin each day, not on blood pressure medication. have not started my cholesterol medication yet.

Overall, I am not getting any side effects that stand out at me other than get some facial flushing when taking Viagra, 100mg split when needed and daily Tadafil 2.5mg.

Your correct, I am taking the lesser dose of Zyosted (50mg). minimal dose correct.

If I pull the trigger on the donation can you give me any insight on preparing before and after the donation?

My trough level before next injection is as follows: Testosterone (TT) 464.50 Free Test.(FT)- 90.9

Thanks @madman for your reply

ZALEMAX said:

@madman not sure 100% how much water I drank before the blood test on or days before but, I had water with me.. I don't think that the effect of the the water consumption is the cause of the upper limit hct. But, from now I'll pay more attention to the amount.

I have some calcium build up in my arteries I'm in the 900'z (Calc score) I take a low dose aspirin each day, not on blood pressure medication. have not started my cholesterol medication yet.

Overall, I am not getting any side effects that stand out at me other than get some facial flushing when taking Viagra, 100mg split when needed and daily Tadafil 2.5mg.

Your correct, I am taking the lesser dose of Zyosted (50mg). minimal dose correct.

If I pull the trigger on the donation can you give me any insight on preparing before and after the donation?

My trough level before next injection is as follows: Testosterone (TT) 464.50 Free Test.(FT)- 90.9

Thanks @madman for your reply

Click to expand...

What lab and testing method (calculated, direct immunoassay, Equilibrium Dialysis or Ultrafiltration) was used for testing your FT?

What is the reference range?

Post a screenshot of your lab results if you can.

Where does your SHBG sit?

Chances are your trough FT is subpar unless your SHBG is low!

How do you feel overall throughout the week on your current protocol?

@madman my labs are done at Baylor Collage of Medicine in Houston,Texas. I see the PA for Dr. Mohit Khera.

Where do you live?

Does Tadilfil raise HCT? I am trying to figure out what would cause my HCT to move up any suggestions to the cause?

See enclosed screen shots of my recent labs TT/FT/ SHBG/Estradiol..

I would say, generally, feeling, good days in the middle zone..I wanted to start at the lower dose of Zyosted 50mg ..to get a sense of how my body would respond to the medication TRT. I went from 165lbs to 180lbs my body fat went up but so did my muscles mass.

appreciate your response @madman.

ZALEMAX said:

@madman my labs are done at Baylor Collage of Medicine in Houston,Texas. I see the PA for Dr. Mohit Khera.

Where do you live?

Does Tadilfil raise HCT? I am trying to figure out what would cause my HCT to move up any suggestions to the cause?

See enclosed screen shots of my recent labs TT/FT/ SHBG/Estradiol..

I would say, generally, feeling, good days in the middle zone..I wanted to start at the lower dose of Zyosted 50mg ..to get a sense of how my body would respond to the medication TRT. I went from 165lbs to 180lbs my body fat went up but so did my muscles mass.

appreciate your response @madman.

Click to expand...

You are in good hands!

Yes smart move starting out low as there will always be time to increase the dose if need be.

I am from Canada and live in the province of Ontario.

Use of a pde5i should have no impact on driving up hematocrit.

Hard to pinpoint what the main issue is here.

Your trough TT and better yet FT is well under where a healthy young male would sit which would be around 13-15 ng/dL when using the cFTV.

If we take your not so stellar trough TT 464.5 ng/dL, normal SHBG 33.1 nmol/L and Albumin 4.3 g/dL (default) then your trough FT 9.67 ng/dL would be sub-par.

Another critical point that needs to be mentioned here which I have stated numerous times on the forum you always have the option of using/relying upon calculated FT which would be the linear law-of-mass action cFTV as it has already been validated twice (1st time was done using TT/SHBG assays no longer available) and was then eventually re-validated using current state-of-the-art ED method (higher order reference method) let alone more recently against CDCs standardized Equilibrium Dialysis assay.

Keep in mind it tends to overestimate FT 20-30%!


* However, the Vermeulen formula exhibits suboptimal accuracy and tends to overestimate measured free T by 20–30%.

* Calculated free T using high-quality T and SHBG assays has been considered the most useful for clinical purposes [99]. All algorithms suffer from some inaccuracies, including the variable quality of SHBG IAs [100], not replicating the non-linear nature of T-SHBG binding, different and inaccurate association constants for SHBG and albumin binding [101], and variable agreement with equilibrium dialysis results [99,100]. However, until further developments in the field materialize, the linear model algorithms [in particular, the most used Vermeulen equation [102]] appear to give, despite a small systematic positive bias, acceptable data for the clinical management and research[37,103].




Looking over your results your FT was calculated!

Your trough TT and better yet FT is well under where a healthy young male would sit which would be around 13-15 ng/dL when using the cFTV.

If we take your not so stellar trough TT 464.5 ng/dL, normal SHBG 33.1 nmol/L and Albumin 4.3 g/dL (default) then your trough FT 9.67 ng/dL would be sub-par.

Again also keep in mind cFTV tends to overestimate so your trough FT would be a little lower if it was tested using the most accurate assay which would be the gold standard Equilibrium Dialysis!



Seeing as you are using the Xyosted auto-injector which is injected once weekly sub-q even though your peak TT and more importantly FT will be much higher your peak-trough would not be as extreme as when injecting strictly IM.

Even then you would still be hitting a healthy peak TT/FT level.

If you truly feel great overall then stick with it but if you feel there is room for improvement than you can look into other options.