SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE OVER 13 YEARS

SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE THERAPY (TTH) OVER 13 YEARS IN MEN WITH FUNCTIONAL HYPOGONADISM (2022)
Farid Saad1,2, Ahmad Haider, Karim Haider, Gheorghe Doros, Abdulmaged Traish Consultant, Bayer AG, Berlin, Germany; Research Department, Guld Medical University, Ajman, UAE Private Urology Practice, Bremerhaven, Germany; Department of Epidemiology and Statistics, Boston University School of Public Health, Boston, MA, USA; Department of Biochemistry and Department of Urology, Boston University School of Medicine, Boston, MA, USA


Introduction: Studies reported inconsistent effects of TTh on the lipid profile in men with hypogonadism.

Methods: In a registry of 797 men with symptomatic functional hypogonadism, 394 men (49.5%) received TTh by testosterone undecanoate (TU) injections 1000mg/12weeks following an initial 6-week interval (T-group). 402 men opted against TTh and served as controls (CTRL). 13-year data are presented. Means and standard deviations of absolute measures over 13 years are reported.

Results: Mean age at baseline: 58.5±6.3 (T-group), 63.2±4.8 (CTRL). Mean (median) follow-up: T-group 10.1±3.0(11), CTRL 10.5±3.0(12) years.


*Total cholesterol (TC) (mmol/L for all lipids) decreased from 8.0±1.1 to 5.1±0.3 (T-group) and increased from 6.6±1.3 to 8.0±1.3 (CTRL) (p<0.0001 for both).

*HDL increased from 1.0±0.3 to 1.6±0.3 (T-group) and decreased from 1.2±0.5 to 0.9±0.4 (CTRL) (p<0.0001 for both).

*The TC: HDL ratio decreased from 9.1±3.6 to 3.3±0.6 (T-group) and increased from 6.5±3.4 to 11.4±5.6 (CTRL) (p<0.0001 for both).

*LDL decreased from 4.4±0.9 to 2.5±0.3 (T-group) and increased from 3.5±1.3 to 4.6±1.5 (CTRL) (p<0.0001 for both).

*Triglycerides (TG) decreased from 3.2±0.6 to 2.2±0.1 (T-group) and increased from 3.0±0.5 to 3.7±0.6 (CTRL) (p<0.0001 for both).

*The LDL: HDL ratio decreased from 5.1±2.5 to 1.7±0.4 (T-group) and increased from 3.6±2.6 to 6.8±4.5 (CTRL) (p<0.0001 for both).

*The HDL:LDL ratio increased from 0.24±0.10 to 0.64±0.13 (T-group) and decreased from 0.41±0.22 to 0.22±0.13 (CTRL) (p<0.0001 for both).

*Non-HDL decreased from 7.0±1.0 to 3.5±0.3 (T-group) and increased from 5.4±1.4 to 7.2±1.4 (CTRL) (p<0.0001 for both).

*Remnant cholesterol decreased from 2.6±0.9 to 1.0±0.3 (T-group) and increased from 1.9±0.9 to 2.6±0.8 (CTRL) (p<0.0001 for both).

*The TG: HDL ratio decreased from 8.4±3.7 to 3.2±0.6 (T-group) and increased from 6.7±3.5 to 11.7±5.7 (CTRL) (p<0.0001 for both).




Conclusion: Long-term treatment with TU in men with functional hypogonadism improved the lipid profile, which worsened in controls.

madman said:

SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE THERAPY (TTH) OVER 13 YEARS IN MEN WITH FUNCTIONAL HYPOGONADISM (2022)
Farid Saad1,2, Ahmad Haider, Karim Haider, Gheorghe Doros, Abdulmaged Traish Consultant, Bayer AG, Berlin, Germany; Research Department, Guld Medical University, Ajman, UAE Private Urology Practice, Bremerhaven, Germany; Department of Epidemiology and Statistics, Boston University School of Public Health, Boston, MA, USA; Department of Biochemistry and Department of Urology, Boston University School of Medicine, Boston, MA, USA


Introduction: Studies reported inconsistent effects of TTh on the lipid profile in men with hypogonadism.

Methods: In a registry of 797 men with symptomatic functional hypogonadism, 394 men (49.5%) received TTh by testosterone undecanoate (TU) injections 1000mg/12weeks following an initial 6-week interval (T-group). 402 men opted against TTh and served as controls (CTRL). 13-year data are presented. Means and standard deviations of absolute measures over 13 years are reported.

Results: Mean age at baseline: 58.5±6.3 (T-group), 63.2±4.8 (CTRL). Mean (median) follow-up: T-group 10.1±3.0(11), CTRL 10.5±3.0(12) years.


*Total cholesterol (TC) (mmol/L for all lipids) decreased from 8.0±1.1 to 5.1±0.3 (T-group) and increased from 6.6±1.3 to 8.0±1.3 (CTRL) (p<0.0001 for both).

*HDL increased from 1.0±0.3 to 1.6±0.3 (T-group) and decreased from 1.2±0.5 to 0.9±0.4 (CTRL) (p<0.0001 for both).

*The TC: HDL ratio decreased from 9.1±3.6 to 3.3±0.6 (T-group) and increased from 6.5±3.4 to 11.4±5.6 (CTRL) (p<0.0001 for both).

*LDL decreased from 4.4±0.9 to 2.5±0.3 (T-group) and increased from 3.5±1.3 to 4.6±1.5 (CTRL) (p<0.0001 for both).

*Triglycerides (TG) decreased from 3.2±0.6 to 2.2±0.1 (T-group) and increased from 3.0±0.5 to 3.7±0.6 (CTRL) (p<0.0001 for both).

*The LDL: HDL ratio decreased from 5.1±2.5 to 1.7±0.4 (T-group) and increased from 3.6±2.6 to 6.8±4.5 (CTRL) (p<0.0001 for both).

*The HDL:LDL ratio increased from 0.24±0.10 to 0.64±0.13 (T-group) and decreased from 0.41±0.22 to 0.22±0.13 (CTRL) (p<0.0001 for both).

*Non-HDL decreased from 7.0±1.0 to 3.5±0.3 (T-group) and increased from 5.4±1.4 to 7.2±1.4 (CTRL) (p<0.0001 for both).

*Remnant cholesterol decreased from 2.6±0.9 to 1.0±0.3 (T-group) and increased from 1.9±0.9 to 2.6±0.8 (CTRL) (p<0.0001 for both).

*The TG: HDL ratio decreased from 8.4±3.7 to 3.2±0.6 (T-group) and increased from 6.7±3.5 to 11.7±5.7 (CTRL) (p<0.0001 for both).




Conclusion: Long-term treatment with TU in men with functional hypogonadism improved the lipid profile, which worsened in controls.

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Interesting, Nelson. At 74, 12 years might or might not be in the cards. I will not touch a statin. I eat many eggs, butter, olive oil(EVOO), shrimp, cheese, homemade pinto beans, kefir(Lifeway). My hsCRP is 4 and PSA is 4.5, though my prostate is 'small and rubbery' per my urologist. Negative for PCa. We both believe this a picture of systemic inflammation. Tried doxycycline but reacted to the fillers and binders, regardless of the dose I used.

I cut out wheat because I believe, for me, it could be contributing to the inflammatory process and inability to lose weight. Eating more salads and potatoes. I always eat fruit. Going to try MSM. Just received my bottle. Also now trying hemp *** gummies w/o THC with the hope of getting off of almost 2 decades on clonazepam. That's going to be difficult and I might have to settle for a minimal dose in the evening.

I've been ready to throw in the towel on testosterone, but I know it improves my mood and maintains muscle mass. I try to do 130 push ups most days but if I didn't sleep good, no desire. Up and down the stairs in our apartment from morning until night. Once measured it. 8000 steps, one day. Getting restorative sleep is my bane, related to bipolar illness.