Recent content by madhacker

He's referring to the paper I posted above. The authors of the paper state that their study was not fully controlled, we're still awaiting further research as Nelson mentioned.

I thought you would find that interesting. In terms of awaiting further data and outcomes with TAME, I agree. I'm looking forward to reviewing data beyond what's easily measurable.

@Nelson Vergel https://diabetesjournals.org/care/article/44/12/2775/138471/Effect-of-Metformin-and-Lifestyle-Interventions-on Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study "Over a median of 21...

I'm curious as well. @Nelson Vergel I'm confused as to what the following statements meant, did it mean that two separate pharmaceutical preparations of preg. led to different level at separate blood draws? "on oral OTC pregnenolone 100 mg per day: Pregnenolone went from undetectable to 95...

*Repost from Madman, very interesting. I have polyglandular autoimmune syndrome 1 (APS-1) and is possibly why I notice such a positive improvement with exogenous GH. IGF-1 has an even greater improvements in myself. Abstract Introduction The GH/IGF-1 axis affects multiple metabolic...

Hi Nelson, Do you think it's safe to take pharmacological doses of growth hormone as you suggest 2mg to correct IGF-1 deficiency? Have you considered the use of IGF-1 therapy in which case? I'm aware of growth hormone 2mg for specified indications, but for long-term HRT I think it may be safer...

If you are unable to stimulate the liver to produce IGF-1 from GH, you may consider IGF-1 therapy. Use a combination of exogenous growth hormone and IGF-1 to correct GH and IGF-1 deficiency. IGF-1 produces roughly 60% of the beneficial effects of growth hormone so you may consider correcting...

Hi Nelson, Have you tried this combination yet? If so, did you experience a decrease in muscle pumps or experience any fatigue? Generally, what was your experience? thanks for your response in advance!

I'm a big fan of the evidence for semaglutide and have recently started taking it for personal researching. I may consider combining with canagliflozin once I get a feel for long-acting GLP-1. I will report back.

Hi Nelson, I have tried this combination and found that I gained muscle and I believe your suspicions are correct, you will not lose your muscle pump or mass, as I did not. The muscle sensitizing effect on muscle seems to be profound in my case, subjectively speaking. My pre-existing concerns...

Hi Nelson, May I ask if you have any updates on your experience with tesamorelin? Have you had your IGF-1 levels determined?

Hi there, You mentioned your IGF-1 levels tripled, may I ask what your IGF-1 serum was before and after your trial? Are you currently taking it? If so what are your levels at these days if you have had them checked? I appreciate your response in advance.

The conboy study showed a substantial reversal of epigenetic aging over the TRIM. https://joshmitteldorf.scienceblog.com/2020/06/08/out-with-the-old-blood/

Hi there, thanks for sharing your experience. What aging tests did you have performed ie. Telomere, epigenetic? Epigenetic aging essentially measures damage that comes with aging so we think that the reversal of age seen in the TRIM study was to do with the increase in size of the thymus...

Nir Barzilai studies centenarians and has found that lower IGF-1 levels in females improve cognitive function and extend lifespan. It has shown to be the opposite in males, not extending lifespan. https://www.amazon.com/Age-Later-Health-Science-Longevity/dp/1250752582...