Recent content by BryanW

During my most recent consult with Dr. Calkins, he recommended starting BPC-157 (250mcg ED SQ) and CJC-1295/Ipamorelin (350mcg ED SQ). The former because I just had surgery to reattach my left distal bicep tendon (8/11/2020), and the latter because my IGF-1 has been trending down over the last...

I am a patient of Defy and currently my status is on hold as I am working with a local endocrinologist to get to the bottom of a suspected thyroid issue. Right now I am having difficulty getting the endo to prescribe thyroid antibody tests (TRAb, TPOAb, and TgAb). I also cannot request my own...

I'd cut the DHEA.

I have no idea. I could be completely wrong, so here is my very simple thought process; low SHBG results in higher clearance rate of testosterone, which limits the available pool from which E2 can aromatize. And any E2 that is aromatized would have a similarly high clearance rate.

Yes I get my script from a compounding pharmacy. I'm a patient with Defy; not sure why Dr. Calkins went with 15 mg instead of 12.5. Maybe because of my weight (210#)? My E2 has increased as my testosterone has gone up, but the number seems reasonable and I haven't noticed any E2 related side...

I'd tell her that you only agree to try if she starts you out at a very low dose (something like 12.5 mg ED, or 25 mg EOD), and you reserve the right to stop at any time if you don't feel any better (or feel worse). For what it's worth, in my case I wanted to try the easy road of taking a pill...

I think that theory only holds if a person had zero estrogen to begin with.

By the way, I've been on 15 mg of Clomid every day for around 11 months. My total testosterone went from 400 to 700 ng/dl, and improvement in strength and sexual function was very pronounced.

For each estrogen receptor an antagonist occupies, that is one less receptor for an estrogen to activate. The net effect is to make your estrogen level appear lower than it actually is, thereby stimulating more LH.

Your understanding of Clomid is not correct; Clomiphene can act as both an estrogen agonist, and an antagonist. source "Clomiphene citrate works as an estrogen antagonist at the level of the pituitary gland and thus stimulates the release of LH and FSH, which in turn drives both the...

I take 15mg ED, and my total is just over 700 ng/dl. But always remember, your mileage may vary.

Not necessarily. For example, the aldosterone and cortisol hormone pathways share many enzymes (e.g., 21-hydroxylase). A deficiency in any of the shared enzymes would affect both pathways. The only way to know for sure is to test both, as well as the relevant hormone precursors.

Have you had blood drawn for the sensitive (LC/MS-MS) Estradiol (E2) test? Your symptoms line up with low E2. Also, anecdotally most of the vision problems on Clomid correlate with starting at too high of a dose (i.e., 50mg).

See this thread for background. Here are my 4-tube salivary cortisol results: Any help interpreting these results would be greatly appreciated.

So here are my results: 6AM: 0.295 11AM: 0.115 5PM: 0.045 11 PM: 0.016 looks like a normal shape, but the values seem low. Is that a correct interpretation? What, if anything, should I follow-up on?