ED/libido are multifactorial.
As you should very well know there is much more involved when it comes to libido let alone ED than just having healthy hormones.
He stated.....
I e tied everything to boost my libido and the only thing that worked was 400mg of test per week ... This isn't a good amount and that was a one off weekly amount to boost my levels .
He basically drove his T levels up from one high-dose injection which most likely spiked dopamine temporarily.
Even then if one continued to follow such a ridiculous protocol of 400 mg T/week it is highly doubtful the boost in libido would be maintained long-term let alone one would feel great overall.
When using exogenous T many factors can come into play when it comes to what dose of T is needed to achieve a healthy FT level.
The dose T, SHBG level, injection frequency, metabolism, the
sensitivity of the AR, polymorphism of the AR, and CAG repeat length (long/short), bodyweight.
Most men can easily achieve a healthy let alone absurdly high trough FT on 100-150 mg T/week whether split twice weekly (every 3.5 days), M/W/F, EOD let alone daily.
Sure some may need the higher end dose of 200 mg T/week to achieve such but it is far from common.
Regarding the thrown-around term
androgen resistance used on the numerous forums littered on the internet especially the ones where everyone and their brother that was struggling on a trt protocol claimed that they need to be running absurdly high trough TT/FT levels to feel good!
If you want to put any weight behind the sensitivity of the AR (androgen receptor) and polymorphism of the AR/CAG repeat length (short/long).....sure!
Some men may need to be running what would be considered very high T levels 1800-2000 ng/dL because of a decreased sensitivity of ARs to androgens due to having a higher CAG repeat length.
Even then the number of men who have a high number of CAG repeat lengths would be far from common.
Highly doubtful one would need absurd doses of T 400 mg/week to overcome this so-called
androgen resistance let alone polymorphism of the AR/
higher CAG repeat length.
Androgen Sensitivity: Beyond the Well-Known © Irina A. Khripun*, Sergey V. Vorobyev Rostov State Medical University, Rostov-on-Don, Russia The gonadal and extragonadal effects of testosterone in men have been actively studied in recent years. To date there is no doubt an increased risk of...
www.excelmale.com
One of the mechanisms by which the action of testosterone is realized is sensitivity to androgens, determined by the length of CAG repeats in the androgen receptor gene. An increase in the number of CAG repeats reduces their activity and is manifested by low sensitivity to testosterone. In contrast, a decrease in the number of trinucleotide repeats is accompanied by an increase in the sensitivity of receptors to androgens.
In recent years, researchers have especially focused on the study of the first exon AR gene, which is characterized by repeats of the sequence of three nucleotides - cytosine, adenine, and guanine - CAG. The CAG triplet encodes the amino acid glutamine, therefore, the amount of glutamine in the protein depends on the number of trinucleotide repeats. So, a smaller number of CAG repeats correspond to a lower degree of conformational changes in the receptor, which makes the connection of the hormone and receptor stronger and leads to an increase in the transcriptional activity of AR. In contrast, with an increase in the number of CAG repeats, the relationship between androgens and the receptor becoming weaker, and transcriptional activity AR is decreasing.
For men of the European population, the number of CAG repeats from 9 to 37 is considered normal. However, there are population differences in this standard. So, the average number of CAG repeats per the AR gene for Europeans is 21, for Africans - 17, for Asians - 23. At the same time, for example, 25 CAG repeats though fit into normative values often associated with weakening the action of androgens, manifested by the corresponding clinical symptoms [8].
