Undecanoate split (NEBIDO/AVEED)
- Thread starter leeault
- Start date
Nelson Vergel
Founder, ExcelMale.com
It would be an interesting experiment to inject 1 cc (333.3 mg) per month of testosterone undecanoate instead of 1000 mg every 3 months. I have not seen pharmacokinetic data on that dose. I do not think that dose will be enough, though. 500 mg per month will be more like it.
Note: Aveed has 750 mg of testosterone undecanoate. Nebido has 1000 mg.
Pharmacokinetics
Absorption
Aveed 750 mg delivers physiologic amounts of testosterone, producing circulation testosterone concentrations that approximate normal concentrations (300-1000 ng/dL) seen in healthy men.
Testosterone esters in oil injected intramuscularly are absorbed from the lipid phase. Cleavage of the undecanoic acid side chain of Aveed by tissue esterases releases testosterone.
Following intramuscular injection of 750 mg of Aveed, serum testosterone concentrations reach a maximum after a median of
7 days (range 4 – 42 days) then slowly decline (Figure 3). Steady state serum testosterone concentration was achieved with the 3rd injection of Aveed at 14 weeks.
Figure 3 shows the mean serum total testosterone concentration-time profile during the 3rd injection interval (at steady state, 14-24 weeks) for hypogonadal men (less than 300 ng/dL) given 750 mg Aveed at initiation, at 4 weeks, and every 10 weeks thereafter. Intramuscular injection of 750 mg of Aveed generates mean steady state serum total testosterone concentrations in the normal range for 10 weeks.
As you can tell, if you want TT to remind above 500 ng/dL, you would have to inject Aveed every month or so.
Note: Aveed has 750 mg of testosterone undecanoate. Nebido has 1000 mg.
Pharmacokinetics
Absorption
Aveed 750 mg delivers physiologic amounts of testosterone, producing circulation testosterone concentrations that approximate normal concentrations (300-1000 ng/dL) seen in healthy men.
Testosterone esters in oil injected intramuscularly are absorbed from the lipid phase. Cleavage of the undecanoic acid side chain of Aveed by tissue esterases releases testosterone.
Following intramuscular injection of 750 mg of Aveed, serum testosterone concentrations reach a maximum after a median of
7 days (range 4 – 42 days) then slowly decline (Figure 3). Steady state serum testosterone concentration was achieved with the 3rd injection of Aveed at 14 weeks.
Figure 3 shows the mean serum total testosterone concentration-time profile during the 3rd injection interval (at steady state, 14-24 weeks) for hypogonadal men (less than 300 ng/dL) given 750 mg Aveed at initiation, at 4 weeks, and every 10 weeks thereafter. Intramuscular injection of 750 mg of Aveed generates mean steady state serum total testosterone concentrations in the normal range for 10 weeks.
As you can tell, if you want TT to remind above 500 ng/dL, you would have to inject Aveed every month or so.
Last edited:
CoastWatcher
Moderator
How many times have you had this roller-coaster effect that you describe, and how do you respond to it?
Nelson Vergel
Founder, ExcelMale.com
Shorter interval between testosterone undecanoate doses may boost levels in hypogonadism
Testosterone undecanoate injected at 8-week intervals for men with hypogonadism may reduce fluctuations and increase mean testosterone levels compared with a 10-week dose regimen, according to data from a modeling study. “The currently approved 10-week dose regimen of testosterone undecanoate...
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