madman
Super Moderator
ABSTRACT
The physiological, clinical, and therapeutic aspects of testosterone in women’s health are still a matter of controversy and debate. Quality evidence data of clinical trials favor the use of transdermal testosterone in postmenopausal women with female sexual dysfunction causing distress. Doses of testosterone should approximate physiological testosterone levels found in premenopausal women, avoiding supraphysiological concentrations that expose women to adverse events. Short-term treatment periods have been shown to be effective and safe in postmenopausal women with hypoactive sexual desire disorder/dysfunction. However, the long-term safety of testosterone use must be determined.
In conclusion, transdermal testosterone therapy has been demonstrated to be effective and safe in well-powered clinical trials for the treatment of HSDD in postmenopausal women, when doses used approximate physiological testosterone levels in premenopausal women. However, further research is needed to deepen our knowledge of the effects of testosterone therapy on cognitive performance, musculoskeletal and cardiovascular health, as well as longterm safety use.
The physiological, clinical, and therapeutic aspects of testosterone in women’s health are still a matter of controversy and debate. Quality evidence data of clinical trials favor the use of transdermal testosterone in postmenopausal women with female sexual dysfunction causing distress. Doses of testosterone should approximate physiological testosterone levels found in premenopausal women, avoiding supraphysiological concentrations that expose women to adverse events. Short-term treatment periods have been shown to be effective and safe in postmenopausal women with hypoactive sexual desire disorder/dysfunction. However, the long-term safety of testosterone use must be determined.
In conclusion, transdermal testosterone therapy has been demonstrated to be effective and safe in well-powered clinical trials for the treatment of HSDD in postmenopausal women, when doses used approximate physiological testosterone levels in premenopausal women. However, further research is needed to deepen our knowledge of the effects of testosterone therapy on cognitive performance, musculoskeletal and cardiovascular health, as well as longterm safety use.
