Response from LabCorp About Their Incorrect Unit Usages For Their Free Testosterone - Direct - Test

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Someone else complaining about this issue:

 
Defy Medical TRT clinic doctor
That is debatable. Free testosterone is NOT fully proportional to T dose. As dose increases, the relative increase of free T is larger due to decreases in SHBG.
OK so best to disregard the LabCorp Free T‘ result and calculate the Free T‘ using, Total T’, SHBG and Albumin from the same group of tests. That in turn raises issues since the online Free T’ calculators seem to come up with different Free T’ values for the same input!

Which online calculator do you favour?

EG Balance My Hormones, Tru-t etc etc?
 
That is debatable. Free testosterone is NOT fully proportional to T dose. As dose increases, the relative increase of free T is larger due to decreases in SHBG.
Proportionality exists regardless of SHBG if one assumption is true: The law of mass action is the only significant driver of the consumption rate of testosterone. If this holds then the consumption rate is directly proportional to free testosterone. Clearly at steady state the dose rate on average must equal the consumption rate. Therefore free testosterone is directly proportional to dose rate.

It doesn't matter if SHBG drops with increasing dose. This affects the rate of increase of total testosterone, not free. Free testosterone must rise linearly with the dose.
 

total and free testosterone versus t dose.jpg
 
Beyond Testosterone Book by Nelson Vergel
LabCorp reports free testosterone that do not make sense even in their "direct" method that goes along with LC/MS.

Example:

View attachment 12602

Free testosterone is around 2% of total testosterone.

In this example, Total Testosterone is 435.8 ng/dL

Two percent of that is 0.02 x 435.8 nd/dL= 8.72 ng/dL= 87.2 pg/mL (units used for free T)

His Free T was reported as 16 pg/mL which is absurd.

Here is an example from Quest (for this test Testosterone, Free, Bioavailable and Total (Upper Limit T 1,500 ng/dL) plus SHBG)


View attachment 12603

This is the total Testosterone by LC/MS and free T by dialysis
View attachment 12607



Quest has a reasonable range AND units.

I have emailed LabCorp several times about this but they ignore it. Dr Saya has done the same thing.

Definitive explanation if you are interested...


Example in goriest of details....



In particular see part II for Labcorb direct FT assay.

If in 100 years 1 person reads this and it helps them understand the situation, then I did truly succeed.
 
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