Gotcha. I still don't understand that analogy for people in the Himalayas. I hear it a lot that with H of 55 up there, no big deal. But what about the cyclists in the 90's that died from EPO? Wouldn't the risk of testosterone induced erythrocytosis function more like EPO, if there's a difference on viscosity? Asking for real.
Fun paper from way back:
jamanetwork.com
So, the first couple weeks after a blood donation, in combination with a dosage drop, is the worst time to make any kind of conclusion it seems like. Blood regeneration in the following 3 weeks is enhanced and then begins to slow down, correct? Maybe another 2 weeks and see another CBC before starting any conclusions?Fun paper from way back:
RATE OF BLOOD REGENERATION AFTER BLOOD LOSS
THE PHLEBOTOMY of the healthy donor is the simplest approach to the study of blood regeneration, since there is a controlled, known amount of blood loss and no impairment of hemopoiesis from disease. However, the measurement of blood regeneration after a single phlebotomy of 500 ml. is difficult...
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I've seen a hematotologist who tested me for genetic polycythemia and it was negative. All good.
journals.lww.com
This one is above my intelligence level. Can you eli5 please?FERROKINETICS IN MAN : Medicine
An abstract is unavailable. This article is available as a PDF only.
Free access.
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
Pretty dense summary of iron transport and kinetics in the human body. Your new favorite book at bedtime?
Update: 2 weeks after blood donation and dose drop to 5mg...
These are reasonable numbers considering that your SHBG is on the low side: mid-range free T, E2/T at 0.36% (~0.3-0.6), calculated free E2 of at least 0.45 pg/mL (~0.3-1.3). It's possible that this estradiol level is less than what's optimal for you, but it's not dangerously low. As it's only been two weeks since the dose reduction you could continue to go lower.
Gotcha; thanks.
Guess my memory is struggling too as I just came on here to post those Labs up! Anyway...newest symptoms is "jelly legs". Unsure what else to call it, but muscles seem to have lost size or maybe glycogen storage and feel like jelly. Wondering if I did go too low...good thing is had some more labs drawn today though to see if any change. Still likely too early to tell if a problem since it's only a little more than 3 weeks since the dosage change. But, if my levels are even lower, should I bump back up a little to maybe 6mg, instead of letting it bottom out, so to speak?
I'd say to stay the course unless free testosterone drops significantly further. How you feel during the transition may not have much bearing on how you will feel after your body has adapted to the new levels. The problem is that the adaptation can take weeks to months. This makes it mentally difficult, but if you keep tweaking the dose then you'll never really know how you would feel in the long run.
I hear ya. Thanks.
Got partial labs from Wednesday...
I reach steady state on Jatenzo in 7 days, but my Total T levels don't settle for 2 months.
Well, roughly 6 weeks into 10mg daily I was at 550 total at trough. Then 2-3 weeks later, I was at 664 about 5 hours after injection. So, I don't know exactly where my trough was at that point, but if guess somewhere around there. That was 2 months ago. Since then, I had a month at 7mg, and then 3 weeks at 5mg. 2 weeks into 5mg, my total T was 414. Then about 10 days later, it's up to 766. For the complete picture, everything except the 766 was through quest MS or whatever with a range of 250-1100. The 766 was a different lab, range 168-758 and its not specified MS or whatever. Could it just be a huge error? I don't quite feel the same as when I was on 10mg. Definitely sleeping better, I think slower facial hair growth, less anxiety and less *negative* energy.
