Can TRT harm healthy kidneys with long term use?

[delmiro]

I’m concerned with the long-term effects of testosterone replacement therapy on kidney function? Can TRT be detrimental to the kidneys long term? Assuming that you started out with healthy kidneys.

Thank you

 

[Vince]

Testosterone replacement therapy (TRT) may delay progression of chronic kidney disease (CKD) and lower the risk of death in men with hypogonadism, new findings presented at the National Kidney Foundation’s 2017 Spring Clinical Meetings suggest.

Testosterone Replacement May Delay CKD Progression

Study demonstrates decreased risk of end-stage renal disease and all-cause mortality.

www.renalandurologynews.com

So I would say, no.

 

[Nelson Vergel]

The impact of long-term Testosterone Therapy (TTh) in renal function (RF) among hypogonadal men: An observational cohort study​

Highlights
• Long-term testosterone treatment improves mainly the metabolic parameters in the hypogonadal men.

• Long-term testosterone treatment shows an increase in GFR, thus improving kidney function.

• Decreased cardiovascular events in long-term testosterone group would directly improves the cardiorenal function.


Abstract
Objectives
Testosterone therapy (TTh) is the main treatment for elderly men with hypogonadism. No evidence of the long-term effectiveness of TTh on renal function is reported to date.

Methods
In this study, we evaluated the long-term TTh of testosterone undecanoate (TU) administration on renal function parameters in 496 symptomatic hypogonadal men, with T levels ≤350 ng/dL. The treatment group (T-group) consisted of 312 patients and obtained TU 1000 mg for 12 weeks followed by 6-week intervals and for up to 8 years. The remaining 184 hypogonadal men, who opted against TTh, served as a control group (C-group). The two groups were similar in criteria prior to treatment. We evaluated renal function by calculating serum creatinine, urea, uric acid, and glomerular filtration rate (GFR) according to Mayo Clinic guidelines for 8 years. This study obeys the ethical guidelines of German medical association according to Section 15 of the Professional Code, document for AY- Ref. EK/CH/AU signed on Jun 2015.

Results
During the study period, the T-group exhibited lower levels of urea (47.0 ± 11.8 to 34.0 ± 13.9 mg/dL), uric acid (6.57 ± 1.2 to 5.49 ± 1.5 mg/dL), serum creatinine (0.90 ± 0.10 to 1.12 ± 0.9 mg/dL), and higher-level in GFR (87.0 ± 12.9 to 98.0 ± 8.0 mL/min/1.73 m2), which were significant. Alternatively, the C-group exhibited an increase in their serum creatinine (1.16 ± 0.31 to 1.19 ± 0.58 mg/dL), an increase in uric acid (5.54 ± 1.2 to 5.44 ± 1.7 mg/dL), and a decrease in GFR (92.0 ± 20.1 to 87.0 ± 26.1 mL/min/1.73 m2). A total of 25 deaths (7.8%) was recorded in the T-group, among them 11 (44%) were cardiovascular. On the other hand, 28 patients (15.2%) died in C-group and all deaths (100%) were found to cardiovascular causes.

Conclusion
The results suggest that long-term TTh could improve renal function in hypogonadal men comparing to slight deterioration observed in patients without intervention. In addition to reduce mortality in cardiovascular patients, almost to the half.

 

[Nelson Vergel]

Can Testosterone Replacement Affect Kidneys?

A study done in rats showed that higher total and free testosterone blood levels produced by testosterone treatment were associated with higher creatinine and lower creatinine clearance Creatinine is a chemical waste product that's produced by your muscle metabolism and to a smaller extent...

www.excelmale.com

Kidney Function 101

Table of Contents What Is Creatinine and Creatinine Clearance? Creatinine is a waste product that is produced continuously during normal muscle breakdown. The kidneys filter creatinine from the blood into the urine, and reabsorb almost none of it. The amount of blood the kidneys can make...

www.excelmale.com

 

[Nelson Vergel]

LONG-TERM TESTOSTERONE THERAPY IMPROVES RENAL FUNCTION IN MEN WITH FUNCTIONAL HYPOGONADISM

LONG-TERM TESTOSTERONE THERAPY IMPROVES RENAL FUNCTION IN MEN WITH FUNCTIONAL HYPOGONADISM: EXPERIENCE FROM AN OBSERVATIONAL REGISTRY STUDY (2022) Karim Sultan Haider, Ahmad Haider, Gheorghe Doros, Farid Saad, Abdulmaged Traish Private Urology Practice, Bremerhaven, Germany; Department of...

www.excelmale.com

 

[Deleted member 43589]

Those of us who are forced to have to take ARBs for high blood pressure also have an added protection.

 

[Fernando Almaguer]

Those of us who are forced to have to take ARBs for high blood pressure also have an added protection.

what about lisinopril which is an ACE?