ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How to Inject Testosterone Intramuscularly, Shallow IM or Subcutaneously ?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 130580" data-attributes="member: 3"><p style="margin-left: 20px"><strong><span style="font-size: 18px">Is there a story behind how Sub-Q injections of testosterone came about? </span></strong></p><p>By D. Bruce</p><p></p><p>Here is a summary of the timeline:</p><p></p><p>1) Over 10-15 years ago there were several progressive doctors in the cash HRT/TRT space who at some point realized subcutaneous administration of testosterone cypionate or enanthate not only absorbed as effectively as IM. They also found that more frequent subcutaneous injections yielded more stable levels than a once per week IM injection. Some of these doctors started writing about it including TRT expert Dr. Eugene Shippen who wrote the book "The Testosterone Syndrome". These doctors may have also found old studies (or did small observational studies themselves) showing that oil-based hormone injections can be administered SC with efficacy. </p><p></p><p>2) Over the years as TRT became more prevalent, experts and physicians have attempted to develop novel ways to administer testosterone. This lead to more formal studies being done on the effects of subcutaneous testosterone injections. </p><p></p><p>3) In addition to formal studies, many progressive doctors also experimented and observed that SC delivery is equal if not superior (in pharmacokinetics) over single larger dosed IM injections.</p><p></p><p>Selection of studies to review:</p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/30296416" target="_blank">A 52-Week Study of Dose-Adjusted Subcutaneous Testosterone Enanthate in Oil Self-Administered via Disposable Auto-injector. - PubMed - NCBI</a></p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29264562" target="_blank">Serum Testosterone Concentrations Remain Stable Between Injections in Patients Receiving Subcutaneous Testosterone. - PubMed - NCBI</a></p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26789709" target="_blank">Subcutaneous Testosterone: An Effective Delivery Mechanism for Masculinizing Young Transgender Men. - PubMed - NCBI</a></p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29367424" target="_blank">Pharmacokinetics, safety, and patient acceptability of subcutaneous versus intramuscular testosterone injection for gender-affirming therapy: A pil... - PubMed - NCBI</a></p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29293461" target="_blank">Daily subcutaneous testosterone for management of testosterone deficiency. - PubMed - NCBI</a></p><p></p><p></p><p><strong>Subcutaneous administration of testosterone. A pilot study report.</strong> Al-Futaisi AM, Al-Zakwani IS, Almahrezi AM, Morris D. Source Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.</p><p></p><p><u>Abstract</u></p><p></p><p><strong>OBJECTIVE:</strong> To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients.</p><p></p><p> <strong>METHODS:</strong> All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Montreal, Quebec, Canada, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administer weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. </p><p></p><p><strong>RESULTS:</strong> A total of 22 patients were enrolled in the study. The mean trough was 14.48 +/- 3.14 nmol/L and peak total testosterone was 21.65 +/- 7.32 nmol/L. For the free testosterone, the average trough was 59.94 +/- 20.60 pmol/L and the peak was 85.17 +/- 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. </p><p></p><p><strong>CONCLUSION</strong>: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.</p><p></p><p><strong>UPDATE</strong>: <strong>Self-Administered Testosterone Injection Meets Main Goal In Late-Stage Study</strong>. Reuters (2/26/2015, Grover) reports that an experimental once-weekly testosterone injection, testosterone enanthate that is to be marketed as QuickShot Testosterone, met its primary goal in the ongoing late-stage study. The study involves 150 patients with less than 300 nanograms of testosterone per deciliter of blood. QuickShot is the only self-administered, subcutaneous treatment currently in late-stage</p><p></p><p style="margin-left: 20px"><strong><span style="font-size: 18px">What is the largest dose of Sub-Q testosterone someone can inject before running into issues ie-nodules, injection site pain, etc?</span></strong></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">The rule of thumb unofficially followed by most doctors is never inject more than 1mL total of a water-based injectable subcutaneously.</p> <p style="margin-left: 20px"></p><p>When it comes to oil-based injectables usually not more than 0.5mL is a low risk of site injections. Going over 0.5ml of an oil-based often leads to discomfort and swelling at the site of injection. 0.5mL or less yields no site issues especially when using grapeseed oil. </p><p style="margin-left: 20px"></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 130580, member: 3"] [INDENT][B][SIZE=18px]Is there a story behind how Sub-Q injections of testosterone came about? [/SIZE][/B][/INDENT] By D. Bruce Here is a summary of the timeline: 1) Over 10-15 years ago there were several progressive doctors in the cash HRT/TRT space who at some point realized subcutaneous administration of testosterone cypionate or enanthate not only absorbed as effectively as IM. They also found that more frequent subcutaneous injections yielded more stable levels than a once per week IM injection. Some of these doctors started writing about it including TRT expert Dr. Eugene Shippen who wrote the book "The Testosterone Syndrome". These doctors may have also found old studies (or did small observational studies themselves) showing that oil-based hormone injections can be administered SC with efficacy. 2) Over the years as TRT became more prevalent, experts and physicians have attempted to develop novel ways to administer testosterone. This lead to more formal studies being done on the effects of subcutaneous testosterone injections. 3) In addition to formal studies, many progressive doctors also experimented and observed that SC delivery is equal if not superior (in pharmacokinetics) over single larger dosed IM injections. Selection of studies to review: [URL='https://www.ncbi.nlm.nih.gov/pubmed/30296416']A 52-Week Study of Dose-Adjusted Subcutaneous Testosterone Enanthate in Oil Self-Administered via Disposable Auto-injector. - PubMed - NCBI[/URL] [URL='https://www.ncbi.nlm.nih.gov/pubmed/29264562']Serum Testosterone Concentrations Remain Stable Between Injections in Patients Receiving Subcutaneous Testosterone. - PubMed - NCBI[/URL] [URL='https://www.ncbi.nlm.nih.gov/pubmed/26789709']Subcutaneous Testosterone: An Effective Delivery Mechanism for Masculinizing Young Transgender Men. - PubMed - NCBI[/URL] [URL='https://www.ncbi.nlm.nih.gov/pubmed/29367424']Pharmacokinetics, safety, and patient acceptability of subcutaneous versus intramuscular testosterone injection for gender-affirming therapy: A pil... - PubMed - NCBI[/URL] [URL='https://www.ncbi.nlm.nih.gov/pubmed/29293461']Daily subcutaneous testosterone for management of testosterone deficiency. - PubMed - NCBI[/URL] [B]Subcutaneous administration of testosterone. A pilot study report.[/B] Al-Futaisi AM, Al-Zakwani IS, Almahrezi AM, Morris D. Source Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman. [U]Abstract[/U] [B]OBJECTIVE:[/B] To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients. [B]METHODS:[/B] All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Montreal, Quebec, Canada, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administer weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. [B]RESULTS:[/B] A total of 22 patients were enrolled in the study. The mean trough was 14.48 +/- 3.14 nmol/L and peak total testosterone was 21.65 +/- 7.32 nmol/L. For the free testosterone, the average trough was 59.94 +/- 20.60 pmol/L and the peak was 85.17 +/- 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. [B]CONCLUSION[/B]: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route. [B]UPDATE[/B]: [B]Self-Administered Testosterone Injection Meets Main Goal In Late-Stage Study[/B]. Reuters (2/26/2015, Grover) reports that an experimental once-weekly testosterone injection, testosterone enanthate that is to be marketed as QuickShot Testosterone, met its primary goal in the ongoing late-stage study. The study involves 150 patients with less than 300 nanograms of testosterone per deciliter of blood. QuickShot is the only self-administered, subcutaneous treatment currently in late-stage [INDENT][B][SIZE=18px]What is the largest dose of Sub-Q testosterone someone can inject before running into issues ie-nodules, injection site pain, etc?[/SIZE][/B][/INDENT] [INDENT][/INDENT] [INDENT][/INDENT] [INDENT]The rule of thumb unofficially followed by most doctors is never inject more than 1mL total of a water-based injectable subcutaneously.[/INDENT] [INDENT][/INDENT] When it comes to oil-based injectables usually not more than 0.5mL is a low risk of site injections. Going over 0.5ml of an oil-based often leads to discomfort and swelling at the site of injection. 0.5mL or less yields no site issues especially when using grapeseed oil. [INDENT][/INDENT] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How to Inject Testosterone Intramuscularly, Shallow IM or Subcutaneously ?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top
