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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
PCT Log (27 Y/O, 3 years on TRT)
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<blockquote data-quote="SeeMac" data-source="post: 280992" data-attributes="member: 46799"><p>Yeah HCG hasn't really been shown to induce any desentization of leydig cells in humans. There are a few that demonstrate hcg shifts the steroidogenisis cascade a bit, likely due to how long hcg binds to the leydig cells compared to LH, but it seems to be temporary (which can be seen from a bunch of studies showing hcg induces two peaks in T, one ~12h after administration and another ~72 hours after, which is 2x its half life). Also probably not a big deal since even if testosterone production gets somewhat downregulated, the leydig cells are still active, just the enzymatic cascade is producing other weak steroids, so the goal of improving leydig cell function is still being achieved.</p></blockquote><p></p>
[QUOTE="SeeMac, post: 280992, member: 46799"] Yeah HCG hasn't really been shown to induce any desentization of leydig cells in humans. There are a few that demonstrate hcg shifts the steroidogenisis cascade a bit, likely due to how long hcg binds to the leydig cells compared to LH, but it seems to be temporary (which can be seen from a bunch of studies showing hcg induces two peaks in T, one ~12h after administration and another ~72 hours after, which is 2x its half life). Also probably not a big deal since even if testosterone production gets somewhat downregulated, the leydig cells are still active, just the enzymatic cascade is producing other weak steroids, so the goal of improving leydig cell function is still being achieved. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
PCT Log (27 Y/O, 3 years on TRT)
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